Mice learn multi-step routes by memorizing subgoal locations

The behavioral strategies that mammals use to learn multi-step routes are unknown. In this study, we investigated how mice navigate shelter in response threats when the direct path is blocked. Initially, they fled toward and negotiated obstacles using sensory cues. Within 20 min, spontaneously adopted a subgoal strategy, initiating escapes by running directly obstacle’s edge. Mice continued escape manner even after obstacle had been removed, indicating of spatial memory. However, standard models learning—habitual movement repetition internal map building—did not explain memories formed. Instead, used hybrid approach: memorizing salient locations encountered during spontaneous ‘practice runs’ shelter. This strategy was also geometrically identical food-seeking task. These results suggest memorization fundamental which rodents efficient new environments. Shamash et al. examine get past an blocking their goal. They found instinctively adopt memory combines elements from both habitual learning cognitive theory.